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[1]薛堃,邢秋娟,吳佶,等.益氣化瘀補腎方聯合抗阻運動治療原發性骨質疏松癥療效研究[J].陜西中醫雜志,2022,(3):321-324.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.012]
　XUE Kun,XING Qiujuan,WU Ji,et al.Effect of Yiqi Huayu Bushen decoction combined with anti-obstructive exercise in the treatment of primary osteoporosis[J].,2022,(3):321-324.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.012]
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益氣化瘀補腎方聯合抗阻運動治療原發性骨質疏松癥療效研究

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《陜西中醫》雜志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期數:: 2022年3期

頁碼:: 321-324

欄目:: 臨床研究

出版日期:: 2022-03-05

文章信息/Info

Title:: Effect of Yiqi Huayu Bushen decoction combined with anti-obstructive exercise in the treatment of primary osteoporosis

作者:: 薛堃¹; 邢秋娟¹; 吳佶¹; 黃春水¹; 暴潔¹; 趙蕓¹; 陸虞蓀¹; 焦丹麗¹; 2; (1.上海中醫藥大學附屬龍華醫院,上海 200051; 2.上海中醫藥大學,上海 200032)

Author(s):: XUE Kun; XING Qiujuan; WU Ji; HUANG Chunshui; BAO Jie; ZHAO Yun; LU Yusun; JIAO Danli; (Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200051,China)

關鍵詞:: 原發性骨質疏松癥; 益氣化瘀補腎方; 抗阻運動; 骨密度; 骨鈣素

Keywords:: Primary osteoporosis; Yiqi Huayu Bushen decoction; Resistance exercise; Bone mineral density; Osteocalcin

分類號:: R 68

DOI:: DOI:10.3969/j.issn.1000-7369.2022.03.012

文獻標志碼:: A

摘要:: 目的:探討益氣化瘀補腎方聯合抗阻運動治療原發性骨質疏松癥的療效及對骨密度(BMD)、骨鈣素(BGP)的影響。方法:選擇150例原發性骨質疏松癥患者,采用抽簽法分為試驗組(n=50)、聯合對照組(n=50)、對照組(n=50)。試驗組給予抗阻運動加內服益氣化瘀補腎方治療,聯合對照組給予抗阻運動加口服阿倫磷酸鈉治療,對照組予口服阿倫磷酸鈉治療,三組均連續治療3個月。比較三組臨床療效、BMD、生活質量評分(SF-36)、BGP、骨堿性磷酸酶(BALP)、β-I型膠原羧基末端交聯肽(β-CTX)、視覺模擬評分(VAS)、中醫證候總積分變化情況。結果:治療后,試驗組總有效率96.00%,聯合對照組總有效率78.00%,對照組總有效率72.00%,三組比較差異有統計學意義(P<0.05)。治療后,試驗組BMD、SF-36評分高于聯合對照組和對照組,差異有統計學意義(均P<0.05)。治療后,試驗組BGP水平高于聯合對照組和對照組,差異有統計學意義(均P<0.05)。治療后,試驗組BALP、β-CTX水平低于聯合對照組和對照組,差異有統計學意義(均P<0.05)。治療后,試驗組VAS評分、中醫證候總積分低于聯合對照組和對照組,差異有統計學意義(均P<0.05)。結論:應用益氣化瘀補腎方聯合抗阻運動治療原發性骨質疏松癥療效較好,可有效改善患者BMD、BGP水平。

Abstract:: Objective:To investigate the curative effect of Yiqi Huayu Bushen decoction combined with anti-obstructive exercise in the treatment of primary osteoporosis and its effect on bone mineral density(BMD)and osteocalcin(BGP).Methods:150 patients with primary osteoporosis were selected and divided into experimental group(n=50),combined control group(n=50)and control group(n=50)by lottery.The experimental group were given anti-resistance exercise and Yiqi Huayu Bushen decoction.The combined control group were given anti-resistance exercise and alendronate.The control group were given alendronate.All the groups were continuously treated for 3 months.Clinical efficacy,BMD,SF-36,BGP,BALP,β-CTX,VAS and TCM syndrome score were compared.Results:After treatment, the total effective rate of the experimental group was 96.00%,the total effective rate of the combined control group was 78.00%,and the total effective rate of the control group was 72.00%,difference statistically significant(P<0.05).After treatment,BMD and SF-36 scores in the experimental group were higher than those in the combined control group and the control group, difference statistically significant(all P<0.05).After treatment,the level of BGP in the experimental group was higher than those in the combined control group and the control group,difference statistically significant(all P<0.05).The levels of BALP and β-CTX in the experimental group were lower than those in the combined control group and the control group,difference statistically significant(all P<0.05).After treatment,VAS score and TCM syndrome score of the experimental group were lower than those in the combined control group and the control group,difference statistically significant(all P<0.05).Conclusion:The application of Yiqi Huayu Bushen decoction combined with anti-obstructive exercise has significant effect on the treatment of primary osteoporosis,which can effectively improve BMD and BGP levels.

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相似文獻/References:

[1]董琪,張快強,昝強,等.劉德玉教授論治原發性骨質疏松癥經驗*[J].陜西中醫雜志,2020,(2):226.

備注/Memo

備注/Memo:: 基金項目:上海市自然科學基金資助項目(15ZR1441600); 上海市衛生健康委員會中醫藥科研項目(2020LP012); 上海市衛生和計劃生育委員會中醫藥科研專項課題(2016LP053); 上海市衛生健康委員會中醫優勢病種培育項目[ZY(2018-2020)-ZYBZ-24]; 上海市長寧區醫學碩博士創新人才基地項目(RCJD2021B07); 上海市長寧區健康委員會科研課題(2019Z006)

更新日期/Last Update: 2022-03-09

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