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[1]陶樂維.不同劑量六味地黃丸對胰島素抵抗小鼠糖代謝及體重的影響[J].陜西中醫雜志,2022,(3):275-278.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.001]
　TAO Lewei.Effects of different doses of Liuwei Dihuang pill on glucose metabolism and body weight in insulin resistance mice[J].,2022,(3):275-278.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.001]
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不同劑量六味地黃丸對胰島素抵抗小鼠糖代謝及體重的影響

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《陜西中醫》雜志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期數:: 2022年3期

頁碼:: 275-278

欄目:: 基礎研究

出版日期:: 2022-03-05

文章信息/Info

Title:: Effects of different doses of Liuwei Dihuang pill on glucose metabolism and body weight in insulin resistance mice

作者:: 陶樂維; (上海中醫藥大學附屬曙光醫院內分泌科,上海 201203)

Author(s):: TAO Lewei; (Department of Endocrinology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

關鍵詞:: 胰島素抵抗; 六味地黃丸; 骨鈣素; 糖代謝; 體重增幅

Keywords:: Insulin resistance; Liuwei Dihuang pill; Osteocalcin; Glucose metabolism; Weight gain

分類號:: R 289

DOI:: DOI:10.3969/j.issn.1000-7369.2022.03.001

文獻標志碼:: A

摘要:: 目的:探討不同劑量六味地黃丸對胰島素抵抗小鼠糖代謝及體重的影響。方法:應用不同劑量六味地黃丸干預高脂飲食誘導的胰島素抵抗小鼠。藥物干預6周后檢測小鼠糖耐量。干預8周后檢測空腹血糖,留取血清檢測空腹胰島素,計算胰島素抵抗指數(HOMA-IR); 檢測未羧化骨鈣素(ucOC)、羧化骨鈣素(cOC),計算兩者之間的比值; 計算藥物干預前后小鼠的體重增幅。對HOMA-IR、骨鈣素、體重增幅兩兩之間做相關性分析。結果:與模型組比較,六味地黃丸各劑量組均能夠改善胰島素抵抗小鼠的糖耐量,尤以六味地黃丸小劑量組的作用顯著。與模型組比較,六味地黃丸小劑量組和六味地黃丸大劑量組可改善胰島素抵抗小鼠的HOMA-IR(均P<0.01),且六味地黃丸小劑量組具有更好的改善作用。與模型組比較,六味地黃丸小劑量組治療前后體重增幅最小,差異有統計學意義(P<0.05)。六味地黃丸中、大劑量組體重增幅與模型組比較,差異無統計學意義(均P>0.05)。體重增幅與HOMA-IR呈正相關(r=0.711,P<0.01); 體重增幅與ucOC/cOC呈負相關(r=-0.387,P<0.01),但與ucOC無相關性(r=-0.141,P>0.05); HOMA-IR與ucOC/cOC呈負相關(r=-0.358,P<0.05),但與ucOC無相關性(r=-0.156,P>0.05)。結論:六味地黃丸小劑量組可更好改善胰島素抵抗小鼠糖耐量和胰島素抵抗,對體重增幅的影響最小,其作用可能與ucOC/cOC有關。

Abstract:: Objective:To investigate effects of different doses of Liuwei Dihuang pill on glucose metabolism and body weight in insulin resistant mice.Methods:Different doses of Liuwei Dihuang pill were used to intervene in high-fat diet-induced insulin resistance mice.Glucose tolerance was measured after 6 weeks of drug intervention.Fasting blood glucose was measured after 8 weeks of intervention and serum taken to detect insulin,uncarboxylated osteocalcin(unOC)and carboxylated osteocalcin(cOC).Insulin resistance index(HOMA-IR)and the ratio of unOC to cOC was calculated(ucOC/cOC),weight gain before and after drug intervention was recorded.Correlation analysis was made between the following indicators such as HOMA-IR,osteocalcin and weight gain.Results:Compared with the model group,each dose of Liuwei Dihuang pill group can improve the glucose tolerance of insulin resistant mice,especially in the low dose group.Compared with the model group,both the low-dose group and high-dose group of Liuwei Dihuang pill can improve HOMA-IR in insulin-resistant mice(all P<0.01).The low-dose group may have better effect.The low-dose group of Liuwei Dihuang pill group had the smallest weight gain,difference statistically significant compared with the model group(P<0.05).The other two groups of Liuwei Dihuang pill group had no statistically significant difference compared with the model group(all P>0.05).Correlation analysis showed that weight gain was significantly positively correlated with HOMA-IR(r=0.711,P<0.01).Weight gain was significantly negatively correlated with ucOC/cOC(r=-0.387,P<0.01),but no significant correlation with ucOC(r=-0.141,P>0.05).HOMA-IR was significantly negatively correlated with ucOC/cOC(r=-0.358,P<0.05),but no significant correlation with ucOC(r=-0.156,P>0.05).Conclusion:The low dose group of Liuwei Dihuang pill could better improve the glucose tolerance and insulin resistance of insulin-resistant mice with the least effect on body weight.Its effect may be related to ucOC/cOC.

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備注/Memo

備注/Memo:: 基金項目:國家自然科學基金青年科學基金資助項目(81302925); 上海市自然科學基金資助項目(19ZR1458300); 中醫糖尿病�？坡撁私ㄔO項目[ZY(2018-2020)-FWTX-4011]; 上海市臨床重點�？祈椖�(SHSLCZDZK05401)

更新日期/Last Update: 2022-03-09

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